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Surprisingly, GPx1 overexpression caused a loss of the protective effect of hypoxic preconditioning that correlated with an attenuation of ERK1/2 activation in the brain [131]

Avoid simultaneous use with strong acids or chelators (e.g., vitamin C or retinol serums) because they can inactivate copper peptides

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Cell-penetrating peptides in glioma Regarding the impermeability of the BBB and cell membrane to therapeutic macromolecules (of large size and low permeability), the incorporation of CPPs, which increase the crossing of the BBB and plasma membrane in peptide-based drug delivery systems, can be a clever solution